Keaton accepted the diamond-and-ruby-encrusted prize on Wednesday at the Hollywood Reporter's 21st annual Women in Entertainment breakfast honouring the most powerful women in Hollywood.
She opened by warning that her speech wasn't funny, then proceeded to crack up the crowd inside the ballroom of the Beverly Hills Hotel.
"I just wanted my speech to be the most touching, heartfelt, funniest, yet also persuasive, because that's what a leader is," the Oscar winner said. "I just knew that my speech had to be way better than Meryl Streep's speech or Jane Fonda or Helen Mirren" - all previous Lansing Award winners.
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